Cancer-miRNA Regulatory Network

Compendium of miRNA Target Genes

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B-CLL Leukemia Haslinger Cluster Number 9 (106 genes) This page contains all miRNA mediated regulation and functional enrichment for B-CLL Leukemia Haslinger cluster number 9. Information about leukemia can be found on Wikipedia, and further information about the "B-CLL Leukemia Haslinger" dataset can be found in Haslinger et al., 2004. Inferred miRNA Mediated Regulation Weeder-miRvestigator PITA TargetScan zzz999 zzz999 hsa-mir-1245 hsa-mir-1245b-5p Gene Ontology Enrichment GO ID GO Term Annotated Genes in Cluster GO:0001775 cell activation 22 GO:0001816 cytokine production 11 GO:0001817 regulation of cytokine production 11 GO:0002376 immune system process 36 GO:0002429 immune response-activating cell surface receptor signaling pathway 6 GO:0002682 regulation of immune system process 20 GO:0002684 positive regulation of immune system process 15 GO:0002694 regulation of leukocyte activation 10 GO:0002696 positive regulation of leukocyte activation 10 GO:0002768 immune response-regulating cell surface receptor signaling pathway 6 GO:0006950 response to stress 40 GO:0006952 defense response 21 GO:0006955 immune response 31 GO:0007165 signal transduction 47 GO:0007166 cell surface receptor linked signaling pathway 32 GO:0007596 blood coagulation 17 GO:0007599 hemostasis 17 GO:0009611 response to wounding 25 GO:0030168 platelet activation 12 GO:0030193 regulation of blood coagulation 4 GO:0031294 lymphocyte costimulation 6 GO:0031295 T cell costimulation 6 GO:0042035 regulation of cytokine biosynthetic process 6 GO:0042060 wound healing 19 GO:0042089 cytokine biosynthetic process 6 GO:0042107 cytokine metabolic process 6 GO:0042108 positive regulation of cytokine biosynthetic process 6 GO:0042110 T cell activation 11 GO:0045086 positive regulation of interleukin-2 biosynthetic process 3 GO:0045321 leukocyte activation 13 GO:0046649 lymphocyte activation 11 GO:0048583 regulation of response to stimulus 28 GO:0050776 regulation of immune response 15 GO:0050778 positive regulation of immune response 9 GO:0050789 regulation of biological process 73 GO:0050817 coagulation 17 GO:0050863 regulation of T cell activation 9 GO:0050865 regulation of cell activation 11 GO:0050867 positive regulation of cell activation 10 GO:0050870 positive regulation of T cell activation 9 GO:0050878 regulation of body fluid levels 17 GO:0050896 response to stimulus 71 GO:0051249 regulation of lymphocyte activation 9 GO:0051251 positive regulation of lymphocyte activation 9 GO:0065007 biological regulation 77 GO:0065008 regulation of biological quality 33 Overlap Between miRNA Target Genes and Enriched Gene Ontology Annotations miRNA Method GO ID GO Term Overlap GO Annotated Genes Cluster Size miRNA Targets Genes P-Value hsa-mir-1245 TargetScan GO:0001775 cell activation 6 22 106 23 0.1575492 hsa-mir-1245b-5p TargetScan GO:0001775 cell activation 6 22 106 23 0.1575492 hsa-mir-1245 TargetScan GO:0001816 cytokine production 4 11 106 23 0.0580231 hsa-mir-1245b-5p TargetScan GO:0001816 cytokine production 4 11 106 23 0.0580231 hsa-mir-1245 TargetScan GO:0001817 regulation of cytokine production 4 11 106 23 0.0580231 hsa-mir-1245b-5p TargetScan GO:0001817 regulation of cytokine production 4 11 106 23 0.0580231 hsa-mir-1245 TargetScan GO:0002376 immune system process 7 36 106 23 0.5554109 hsa-mir-1245b-5p TargetScan GO:0002376 immune system process 7 36 106 23 0.5554109 hsa-mir-1245 TargetScan GO:0002429 immune response-activating cell surface receptor signaling pathway 1 6 106 23 0.3872822 hsa-mir-1245b-5p TargetScan GO:0002429 immune response-activating cell surface receptor signaling pathway 1 6 106 23 0.3872822 hsa-mir-1245 TargetScan GO:0002682 regulation of immune system process 5 20 106 23 0.2368543 hsa-mir-1245b-5p TargetScan GO:0002682 regulation of immune system process 5 20 106 23 0.2368543 hsa-mir-1245 TargetScan GO:0002684 positive regulation of immune system process 4 15 106 23 0.195997 hsa-mir-1245b-5p TargetScan GO:0002684 positive regulation of immune system process 4 15 106 23 0.195997 hsa-mir-1245 TargetScan GO:0002694 regulation of leukocyte activation 3 10 106 23 0.1421833 hsa-mir-1245b-5p TargetScan GO:0002694 regulation of leukocyte activation 3 10 106 23 0.1421833 hsa-mir-1245 TargetScan GO:0002696 positive regulation of leukocyte activation 3 10 106 23 0.1421833 hsa-mir-1245b-5p TargetScan GO:0002696 positive regulation of leukocyte activation 3 10 106 23 0.1421833 hsa-mir-1245 TargetScan GO:0002768 immune response-regulating cell surface receptor signaling pathway 1 6 106 23 0.3872822 hsa-mir-1245b-5p TargetScan GO:0002768 immune response-regulating cell surface receptor signaling pathway 1 6 106 23 0.3872822 hsa-mir-1245 TargetScan GO:0006950 response to stress 10 40 106 23 0.1874733 hsa-mir-1245b-5p TargetScan GO:0006950 response to stress 10 40 106 23 0.1874733 hsa-mir-1245 TargetScan GO:0006952 defense response 5 21 106 23 0.2809127 hsa-mir-1245b-5p TargetScan GO:0006952 defense response 5 21 106 23 0.2809127 hsa-mir-1245 TargetScan GO:0006955 immune response 7 31 106 23 0.3382923 hsa-mir-1245b-5p TargetScan GO:0006955 immune response 7 31 106 23 0.3382923 hsa-mir-1245 TargetScan GO:0007165 signal transduction 10 47 106 23 0.4412041 hsa-mir-1245b-5p TargetScan GO:0007165 signal transduction 10 47 106 23 0.4412041 hsa-mir-1245 TargetScan GO:0007166 cell surface receptor linked signaling pathway 7 32 106 23 0.3809719 hsa-mir-1245b-5p TargetScan GO:0007166 cell surface receptor linked signaling pathway 7 32 106 23 0.3809719 hsa-mir-1245 TargetScan GO:0007596 blood coagulation 5 17 106 23 0.1241904 hsa-mir-1245b-5p TargetScan GO:0007596 blood coagulation 5 17 106 23 0.1241904 hsa-mir-1245 TargetScan GO:0007599 hemostasis 5 17 106 23 0.1241904 hsa-mir-1245b-5p TargetScan GO:0007599 hemostasis 5 17 106 23 0.1241904 hsa-mir-1245 TargetScan GO:0009611 response to wounding 6 25 106 23 0.2696046 hsa-mir-1245b-5p TargetScan GO:0009611 response to wounding 6 25 106 23 0.2696046 hsa-mir-1245 TargetScan GO:0030168 platelet activation 4 12 106 23 0.08447346 hsa-mir-1245b-5p TargetScan GO:0030168 platelet activation 4 12 106 23 0.08447346 hsa-mir-1245 TargetScan GO:0030193 regulation of blood coagulation 1 4 106 23 0.2046841 hsa-mir-1245b-5p TargetScan GO:0030193 regulation of blood coagulation 1 4 106 23 0.2046841 hsa-mir-1245 TargetScan GO:0031294 lymphocyte costimulation 1 6 106 23 0.3872822 hsa-mir-1245b-5p TargetScan GO:0031294 lymphocyte costimulation 1 6 106 23 0.3872822 hsa-mir-1245 TargetScan GO:0031295 T cell costimulation 1 6 106 23 0.3872822 hsa-mir-1245b-5p TargetScan GO:0031295 T cell costimulation 1 6 106 23 0.3872822 hsa-mir-1245 TargetScan GO:0042035 regulation of cytokine biosynthetic process 3 6 106 23 0.01936062 hsa-mir-1245b-5p TargetScan GO:0042035 regulation of cytokine biosynthetic process 3 6 106 23 0.01936062 hsa-mir-1245 TargetScan GO:0042060 wound healing 5 19 106 23 0.1956693 hsa-mir-1245b-5p TargetScan GO:0042060 wound healing 5 19 106 23 0.1956693 hsa-mir-1245 TargetScan GO:0042089 cytokine biosynthetic process 3 6 106 23 0.01936062 hsa-mir-1245b-5p TargetScan GO:0042089 cytokine biosynthetic process 3 6 106 23 0.01936062 hsa-mir-1245 TargetScan GO:0042107 cytokine metabolic process 3 6 106 23 0.01936062 hsa-mir-1245b-5p TargetScan GO:0042107 cytokine metabolic process 3 6 106 23 0.01936062 hsa-mir-1245 TargetScan GO:0042108 positive regulation of cytokine biosynthetic process 3 6 106 23 0.01936062 hsa-mir-1245b-5p TargetScan GO:0042108 positive regulation of cytokine biosynthetic process 3 6 106 23 0.01936062 hsa-mir-1245 TargetScan GO:0042110 T cell activation 3 11 106 23 0.1902749 hsa-mir-1245b-5p TargetScan GO:0042110 T cell activation 3 11 106 23 0.1902749 hsa-mir-1245 TargetScan GO:0045086 positive regulation of interleukin-2 biosynthetic process 2 3 106 23 0.009179971 hsa-mir-1245b-5p TargetScan GO:0045086 positive regulation of interleukin-2 biosynthetic process 2 3 106 23 0.009179971 hsa-mir-1245 TargetScan GO:0045321 leukocyte activation 4 13 106 23 0.1165516 hsa-mir-1245b-5p TargetScan GO:0045321 leukocyte activation 4 13 106 23 0.1165516 hsa-mir-1245 TargetScan GO:0046649 lymphocyte activation 3 11 106 23 0.1902749 hsa-mir-1245b-5p TargetScan GO:0046649 lymphocyte activation 3 11 106 23 0.1902749 hsa-mir-1245 TargetScan GO:0048583 regulation of response to stimulus 7 28 106 23 0.220367 hsa-mir-1245b-5p TargetScan GO:0048583 regulation of response to stimulus 7 28 106 23 0.220367 hsa-mir-1245 TargetScan GO:0050776 regulation of immune response 3 15 106 23 0.4164558 hsa-mir-1245b-5p TargetScan GO:0050776 regulation of immune response 3 15 106 23 0.4164558 hsa-mir-1245 TargetScan GO:0050778 positive regulation of immune response 2 9 106 23 0.303771 hsa-mir-1245b-5p TargetScan GO:0050778 positive regulation of immune response 2 9 106 23 0.303771 hsa-mir-1245 TargetScan GO:0050789 regulation of biological process 16 73 106 23 0.3750707 hsa-mir-1245b-5p TargetScan GO:0050789 regulation of biological process 16 73 106 23 0.3750707 hsa-mir-1245 TargetScan GO:0050817 coagulation 5 17 106 23 0.1241904 hsa-mir-1245b-5p TargetScan GO:0050817 coagulation 5 17 106 23 0.1241904 hsa-mir-1245 TargetScan GO:0050863 regulation of T cell activation 2 9 106 23 0.303771 hsa-mir-1245b-5p TargetScan GO:0050863 regulation of T cell activation 2 9 106 23 0.303771 hsa-mir-1245 TargetScan GO:0050865 regulation of cell activation 3 11 106 23 0.1902749 hsa-mir-1245b-5p TargetScan GO:0050865 regulation of cell activation 3 11 106 23 0.1902749 hsa-mir-1245 TargetScan GO:0050867 positive regulation of cell activation 3 10 106 23 0.1421833 hsa-mir-1245b-5p TargetScan GO:0050867 positive regulation of cell activation 3 10 106 23 0.1421833 hsa-mir-1245 TargetScan GO:0050870 positive regulation of T cell activation 2 9 106 23 0.303771 hsa-mir-1245b-5p TargetScan GO:0050870 positive regulation of T cell activation 2 9 106 23 0.303771 hsa-mir-1245 TargetScan GO:0050878 regulation of body fluid levels 5 17 106 23 0.1241904 hsa-mir-1245b-5p TargetScan GO:0050878 regulation of body fluid levels 5 17 106 23 0.1241904 hsa-mir-1245 TargetScan GO:0050896 response to stimulus 16 71 106 23 0.2961881 hsa-mir-1245b-5p TargetScan GO:0050896 response to stimulus 16 71 106 23 0.2961881 hsa-mir-1245 TargetScan GO:0051249 regulation of lymphocyte activation 2 9 106 23 0.303771 hsa-mir-1245b-5p TargetScan GO:0051249 regulation of lymphocyte activation 2 9 106 23 0.303771 hsa-mir-1245 TargetScan GO:0051251 positive regulation of lymphocyte activation 2 9 106 23 0.303771 hsa-mir-1245b-5p TargetScan GO:0051251 positive regulation of lymphocyte activation 2 9 106 23 0.303771 hsa-mir-1245 TargetScan GO:0065007 biological regulation 17 77 106 23 0.3452546 hsa-mir-1245b-5p TargetScan GO:0065007 biological regulation 17 77 106 23 0.3452546 hsa-mir-1245 TargetScan GO:0065008 regulation of biological quality 8 33 106 23 0.2448584 hsa-mir-1245b-5p TargetScan GO:0065008 regulation of biological quality 8 33 106 23 0.2448584

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